Define if you just need to clean the cover or the whole bed. If it's just the cover, unzip and remove the pillow, zip the cover securely and toss it in the washer in cold temperature (please use easy care washing). To dry, we recommend machine dry, air fluff, no heat. The Comfort Mat foam pillow comes with a water resistant pillow liner. Therefore, a wet cloth is sufficient to clean its exterior. We recommend to use a dry cloth to remove the humidity before reassembling the bed again.